italian version
Aims :
The aim is to provide knowledge of basic processes
of modelling and experiment design for quantitative
evaluation of characteristic parameters of cardiovascular
system and short-term regulatory mechanisms of
systemic pressure.
Topics :
Modelling of cardiovascular system:
general problems. Basic concepts of analogy among
systems of different physical nature. Electrical
activity of the heart. Rudiments of haemodynamics.
Fourier analysis of ECG and aortic pressure and
flow pulse waves. Mechanical properties of the
arterial wall. Arterial compliance. Models of
elastic and viscoelastic arterial walls. Vascular
impedance. Ascending aortic input impedance as
left ventricular afterload. Lumped parameter (windkessel)
models and related problems in experimental identifiability,
parameter estimation and physiological interpretation.
The systemic circulation as intrinsic control
factor of cardiac output: Guyton model. Baroreflex
regulation of systemic arterial pressure and total
systemic autoregulation. Open-loop experiments
for measurement of baroreflex gain. Models for
indirect estimation of baroreflex gain from closed-loop
experiments.
Textbooks :
Belardinelli E., Valli G. e Marchesi C. Bioingegneria
del Sistema Cardiovascolare. Bologna: Patron,
1987.
Burattini R. Identification and Physiological
Interpretation of Aortic Impedance in Modelling.
In: Modelling Methodology for Physiology and Medicine,
Carson E & Cobelli C Eds., pp. 213-252. New
York, Academic, 2001.
Burattini R., Borgdorff P., Westerhof N. The baroreflex
is counteracted by autoregulation, thereby preventing
circulatory instability. Experimental Physiology,
89: 397-405, 2004.
Milnor W.R. Hemodynamics. Baltimore, Williams
& Wilkins, 1989.
Nichols WW, and O’Rourke MF. McDonald's
Blood Flow in Arteries. London: Edward Arnold,
1990.
Lecture notes.
Exam :
Students undergo written examination.
Oral examination is optional for candidates who
are willing to modify the mark got in their written
test, on condition that this mark is not lower
than 18/30.
Tutorial Session :
Tuesday: 9.00 – 12.00
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